Staircase, rest contractions, and potentiation in the isolated rat heart
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چکیده
منابع مشابه
Rested-state contractions and rest potentiation in spontaneously hypertensive rats.
To gain further insight into the excitation-contraction coupling mechanisms in hypertrophy, we studied rested-state contractions, rest decay curves, and rest potentiation under different experimental conditions using papillary muscles of spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar and Wistar-Kyoto (WKY) rats. Under constant stimulation at 1.1 Hz, contractility and ...
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The apparent lack of a positive staircase effect in ray myocardium may reflect inadequate metabolic support. Isolated rat hearts (n equals 10) were perfused at 37 degrees C with Krebs buffer containing 5 mM glucose. In 10 preparations increases in heart rate from 240 to 480/min resulted in twofold increases in left ventricular pressure and dP/dt. Pacing at a rate of 480/min resulted in mechanic...
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Ketotifen is a benzocycloheptathiophene with a range of pharmacological activities. The present study was carried out to evaluate the action of ketotifen on isolated rat bladder contractions induced by KCI and acetylcholine, compared with the effects of other drugs. Ketotifen (5 µM) reduced the response to acetylcholine on rat isolated bladder without altering the maximum response and shift...
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Background: It has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. However, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. Objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in is...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Legacy Content
سال: 1962
ISSN: 0002-9513
DOI: 10.1152/ajplegacy.1962.202.4.636